A short tool to screen HIV-infected patients for mild neurocognitive disorders - a pilot study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3183065
Author(s) Fasel, Dominique; Kunze, Ursula; Elzi, Luigia; Werder, Vreni; Niepmann, Susanne; Monsch, Andreas U.; Schumacher, Rahel; Battegay, Manuel
Author(s) at UniBasel Monsch, Andreas U.
Year 2014
Title A short tool to screen HIV-infected patients for mild neurocognitive disorders - a pilot study
Journal BMC Psychology
Volume 2
Number 1
Pages / Article-Number 21
Abstract We aimed to evaluate the accuracy and acceptability of a short screening test battery for mild neurocognitive deficits.; HIV-infected individuals with a suppressed viral load were examined at the University Hospital Basel with a screening test consisting of a questionnaire and selected cognitive tests, administered by trained nurses, followed by an in-depth neuropsychological examination. Test acceptance was evaluated with a questionnaire.; 30 patients were included in this study (median age of 52.5 years (interquartile range (IQR) 47-64), prior AIDS-defining condition in 37%, median CD4 cell count 658 (IQR 497-814) cells/μl). Overall, 25 (83%) patients were diagnosed with HIV-associated neurocognitive disorders (HAND) on in-depth neuropsychological assessment (16 patients had asymptomatic neurocognitive impairment (ANI), 8 a mild neurocognitive disorder (MND) and 1 patient HIV-associated dementia (HAD). Among 25 patients with HAND, only 9 patients (36%) were complaining of memory loss. The screening battery revealed neurocognitive deficits in 17 (57%) patients (sensitivity 64%, specificity 80%, positive predictive value 94% and negative predictive value 31%). Most patients (83%) estimated the screening test as valuable and not worrisome.; A questionnaire combined with selected neuropsychological tests is a short, easy-to-perform very well accepted screening tool for mild neurocognitive disorders in asymptomatic HIV-infected individuals.
Publisher BioMed Central
ISSN/ISBN 2050-7283
edoc-URL http://edoc.unibas.ch/51830/
Full Text on edoc No
Digital Object Identifier DOI 10.1186/2050-7283-2-21
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25815192
ISI-Number MEDLINE:25815192
Document type (ISI) Journal Article

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