Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3183058
Author(s) Richiardi, Jonas; Monsch, Andreas U.; Haas, Tanja; Barkhof, Frederik; Van de Ville, Dimitri; Radü, Ernst W.; Kressig, Reto W.; Haller, Sven
Author(s) at UniBasel Monsch, Andreas U.
Year 2015
Title Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease
Journal Neurobiology of Aging
Volume 36
Number 1
Pages / Article-Number 33-41
Mesh terms Aged; Aged, 80 and over; Alzheimer Disease, psychology; Blood Flow Velocity; Carbon Dioxide, blood; Cerebrovascular Circulation; Cognition; Cognitive Dysfunction, psychology; Female; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Oxygen, blood
Abstract Interindividual variation in neurovascular reserve and its relationship with cognitive performance is not well understood in imaging in neurodegeneration. We assessed the neurovascular reserve in amnestic mild cognitive impairment (aMCI) and Alzheimer's dementia (AD). Twenty-eight healthy controls (HC), 15 aMCI, and 20 AD patients underwent blood oxygen level-dependent imaging for 9 minutes, breathing alternatively air and 7% carbon dioxide mixture. The data were parcellated into 88 anatomic regions, and carbon dioxide regressors accounting for different washin and washout velocities were fitted to regional average blood oxygen level-dependent signals. Velocity of cerebrovascular reactivity (CVR) was analyzed and correlated with cognitive scores. aMCI and AD patients had significantly slower response than HC (mean time to reach 90% of peak: HC 33 seconds, aMCI and AD 59 seconds). CVR velocity correlated with Mini Mental State Examination in 35 of 88 brain regions (p = 0.019, corrected for multiple comparisons), including 10 regions of the default-mode network, an effect modulated by age. This easily applicable protocol yielded a practical assessment of CVR in cognitive decline.
Publisher Elsevier
ISSN/ISBN 0197-4580 ; 1558-1497
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.neurobiolaging.2014.07.020
PubMed ID
ISI-Number WOS:000347408600006
Document type (ISI) Journal Article

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