Age-shifting in malaria incidence as a result of induced immunological deficit : a simulation study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3180888
Author(s) Pemberton-Ross, Peter; Smith, Thomas A; Hodel, Eva Maria; Kay, Katherine; Penny, Melissa A
Author(s) at UniBasel Pemberton-Ross, Peter
Smith, Thomas
Penny, Melissa
Year 2015
Title Age-shifting in malaria incidence as a result of induced immunological deficit : a simulation study
Journal Malaria journal
Volume 14
Pages / Article-Number 287
Keywords Malaria, Epidemiology, Vaccines, Chemoprevention, Age shift
Abstract

Effective population-level interventions against Plasmodium falciparum malaria lead to age-shifts, delayed morbidity or rebounds in morbidity and mortality whenever they are deployed in ways that do not permanently interrupt transmission. When long-term intervention programmes target specific age-groups of human hosts, the age-specific morbidity rates ultimately adjust to new steady-states, but it is very difficult to study these rates and the temporal dynamics leading up to them empirically because the changes occur over very long time periods. This study investigates the age and magnitude of age- and time- shifting of incidence induced by either pre-erythrocytic vaccination (PEV) programmes or seasonal malaria chemo-prevention (SMC), using an ensemble of individual-based stochastic simulation models of P. falciparum dynamics. The models made various assumptions about immunity decay, transmission heterogeneity and were parameterized with data on both age-specific infection and disease incidence at different levels of exposure, on the durations of different stages of the parasite life-cycle and on human demography. Effects of transmission intensity, and of levels of access to malaria treatment were considered. While both PEV and SMC programmes are predicted to have overall strongly positive health effects, a shift of morbidity into older children is predicted to be induced by either programme if transmission levels remain static and not reduced by other interventions. Predicted shifting of burden continue into the second decade of the programme. Even if long-term surveillance is maintained it will be difficult to avoid mis-attribution of such long-term changes in age-specific morbidity patterns to other factors. Conversely, short-lived transient changes in incidence measured soon after introduction of a new intervention may give over-positive views of future impacts. Complementary intervention strategies could be designed to specifically protect those age-groups at risk from burden shift.

Publisher BioMed Central
ISSN/ISBN 1475-2875
edoc-URL http://edoc.unibas.ch/dok/A6419752
Full Text on edoc Available
Digital Object Identifier DOI 10.1186/s12936-015-0805-1
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/26206255
ISI-Number WOS:000358400600002
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.446 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
10/08/2020