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Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3135029
Author(s) Salehi, Iraj; Hosseini, Seyed Mohammad; Haghighi, Mohammad; Jahangard, Leila; Bajoghli, Hafez; Gerber, Markus; Pühse, Uwe; Kirov, Roumen; Holsboer-Trachsler, Edith; Brand, Serge
Author(s) at UniBasel Holsboer-Trachsler, Edith
Pühse, Uwe
Gerber, Markus
Brand, Serge
Year 2014
Title Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder
Journal Journal of Psychiatric Research
Volume 57
Pages / Article-Number 117-24
Keywords Treatment-resistant major depressive, disorder, Electroconvulsive therapy, Aerobic exercise training, BDNF
Mesh terms Adult; Biomarkers, blood; Brain-Derived Neurotrophic Factor, blood; Depressive Disorder, Major, therapy; Depressive Disorder, Treatment-Resistant, therapy; Electroconvulsive Therapy, psychology; Exercise, psychology; Female; Humans; Male; Treatment Outcome
Abstract To treat patients suffering from treatment-resistant major depressive disorder (TR-MDD), research has focused on electroconvulsive therapy (ECT) and aerobic exercise training (AET). Brain derived neurotrophic factor (BDNF) seems to be key in MDD. The aims of the present study were therefore two-fold, to investigate in a three-arm interventional study the differential effects of ECT, ECT plus AET, and AET alone in patients suffering from TR-MDD on 1. depressive symptoms and 2.; 60 patients with TR-MDD (mean age: 31 years; 31.6% female patients) were randomly assigned either to the ECT, ECT + AET, or AET condition. The AET condition consisted of treadmill exercise for 30 min, three times a week. Both depression severity and BDNF levels were assessed at baseline and 4 weeks later. All patients were further treated with an SSRI standard medication.; BDNF levels increased over time in all three study conditions. After completion of the intervention program, the ECT group showed significantly higher BDNF levels compared to the ECT + AET and the AET conditions. Depressive symptoms decreased in all three conditions over time. The combination of ECT + AET led to a significantly greater decrease than in either the ECT or AET alone conditions. BDNF levels were not associated with symptoms of depression.; The pattern of results suggests that ECT, AET and particularly their combination are promising directions for treatment patients suffering from TR-MDD, and that it remains unclear to what extent BDNF is key and a reliable biomarker for TR-MDD.
Publisher Elsevier
ISSN/ISBN 0022-3956 ; 1879-1379
edoc-URL http://edoc.unibas.ch/dok/A6390939
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jpsychires.2014.06.018
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25073431
ISI-Number 000341550100015
Document type (ISI) Journal Article, Randomized Controlled Trial
 
   

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21/06/2024