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OPERAM: Optimising PharmacothERApy in the Multimorbid elderly
Third-party funded project |
Project title |
OPERAM: Optimising PharmacothERApy in the Multimorbid elderly |
Principal Investigator(s) |
Schwenkglenks, Matthias
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Co-Investigator(s) |
Szucs, Thomas Ademi, Zanfina
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Organisation / Research unit |
Departement Public Health / Pharmazeutische Medizin ECPM, Departement Public Health / Pharmazeutische Medizin (Szucs) |
Project Website |
http://operam-2020.eu/index.php?id=1488 |
Project start |
01.05.2015 |
Probable end |
30.04.2020 |
Status |
Completed |
Abstract |
The overall aim of OPERAM (OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly) is to optimise existing pharmacological and non-pharmacological therapy primarily in order to reduce avoidable hospital admissions among the elderly population aged ≥70 years with multimorbidity.
Specifically, the OPERAM consortium aims at:
- Creating new evidence to prevent avoidable hospital admissions through optimising pharmacotherapy in the multimorbid elderly by performing a multi-centre cluster randomised clinical trial (RCT) to assess the impact of a structured medication review
- Obtaining evidence-based data comparing pharmacological and non-pharmacological interventions to prevent common causes of avoidable hospital admissions in the elderly with multimorbidity, and rank these interventions according to their effectiveness and safety using network meta-analyses (NMA)
- Identify the most cost-effective pharmacological and non-pharmacological interventions to prevent avoidable hospital admissions in the multimorbid elderly
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Keywords |
Elderly, polypharmacy, pharmacotherapy optimisation, health services research, drug-related hospital admissions |
Financed by |
Commission of the European Union Swiss Government (Research Cooperations)
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Published results () |
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ID |
Autor(en) |
Titel |
ISSN / ISBN |
Erschienen in |
Art der Publikation |
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4604333 |
Bhadhuri, Arjun; Kind, Paul; Salari, Paola; Jungo, Katharina Tabea; Boland, Benoît; Byrne, Stephen; Hossmann, Stefanie; Dalleur, Olivia; Knol, Wilma; Moutzouri, Elisavet; O'Mahony, Denis; Murphy, Kevin D.; Wisselink, Linda; Rodondi, Nicolas; Schwenkglenks, Matthias |
Measurement properties of EQ-5D-3L and EQ-5D-5L in recording self-reported health status in older patients with substantial multimorbidity and polypharmacy |
1477-7525 |
Health and quality of life outcomes |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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4525711 |
Adam, Luise; Moutzouri, Elisavet; Baumgartner, Christine; Loewe, Axel Lennart; Feller, Martin; M'Rabet-Bensalah, Khadija; Schwab, Nathalie; Hossmann, Stefanie; Schneider, Claudio; Jegerlehner, Sabrina; Floriani, Carmen; Limacher, Andreas; Jungo, Katharina Tabea; Huibers, Corlina Johanna Alida; Streit, Sven; Schwenkglenks, Matthias; Spruit, Marco; Van Dorland, Anette; Donzé, Jacques; Kearney, Patricia M.; Jüni, Peter; Aujesky, Drahomir; Jansen, Paul; Boland, Benoit; Dalleur, Olivia; Byrne, Stephen; Knol, Wilma; Spinewine, Anne; O'Mahony, Denis; Trelle, Sven; Rodondi, Nicolas |
Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial |
2044-6055 |
BMJ open |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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4625678 |
Blum, Manuel R; Sallevelt, Bastiaan T G M; Spinewine, Anne; O'Mahony, Denis; Moutzouri, Elisavet; Feller, Martin; Baumgartner, Christine; Roumet, Marie; Jungo, Katharina Tabea; Schwab, Nathalie; Bretagne, Lisa; Beglinger, Shanthi; Aubert, Carole E; Wilting, Ingeborg; Thevelin, Stefanie; Murphy, Kevin; Huibers, Corlina J A; Drenth-van Maanen, A Clara; Boland, Benoit; Crowley, Erin; Eichenberger, Anne; Meulendijk, Michiel; Jennings, Emma; Adam, Luise; Roos, Marvin J; Gleeson, Laura; Shen, Zhengru; Marien, Sophie; Meinders, Arend-Jan; Baretella, Oliver; Netzer, Seraina; de Montmollin, Maria; Fournier, Anne; Mouzon, Ariane; O'Mahony, Cian; Aujesky, Drahomir; Mavridis, Dimitris; Byrne, Stephen; Jansen, Paul A F; Schwenkglenks, Matthias; Spruit, Marco; Dalleur, Olivia; Knol, Wilma; Trelle, Sven; Rodondi, Nicolas |
Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial. |
1756-1833 |
BMJ (Clinical research ed.) |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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