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Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2994530
Author(s) Inahashi, Yuki; Iwatsuki, Masato; Ishiyama, Aki; Matsumoto, Atsuko; Hirose, Tomoyasu; Oshita, Jun; Sunazuka, Toshiaki; Panbangred, Watanalai; Takahashi, Yoko; Kaiser, Marcel; Otoguro, Kazuhiko; Ōmura, Satoshi
Author(s) at UniBasel Kaiser, Marcel
Year 2015
Title Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036
Journal Organic letters
Volume 17
Number 4
Pages / Article-Number 864-7
Abstract

Five new anti-trypanosomal macrolides, actinoallolides A-E (1-5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute stereochemistry, were elucidated by a combination of spectroscopic analyses and a series of chemical derivatization studies. Actinoallolide A showed the most potent and selective in vitro anti-trypanosomal activity without cytotoxicity. A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease.

Publisher American Chemical Society
ISSN/ISBN 1523-7060
edoc-URL http://edoc.unibas.ch/dok/A6357878
Full Text on edoc No
Digital Object Identifier DOI 10.1021/ol5037216
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25635351
ISI-Number WOS:000349942600026
Document type (ISI) Journal Article
 
   

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29/03/2024