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Interaction between asthma and smoking increases the risk of adult airway obstruction
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2993515
Author(s) Aanerud, Marianne; Carsin, Anne-Elie; Sunyer, Jordi; Dratva, Julia; Gislason, Thorarinn; Jarvis, Deborah; deMarco, Roberto; Raherison, Chantal; Wjst, Matthias; Dharmage, Shyamali C.; Svanes, Cecilie
Author(s) at UniBasel Dratva, Julia
Year 2015
Title Interaction between asthma and smoking increases the risk of adult airway obstruction
Journal The European respiratory journal
Volume 45
Number 3
Pages / Article-Number 635-43
Abstract The aim of the present study was to analyse the interaction between asthma and smoking in the risk of adult airway obstruction, accounting for atopy. In the European Community Respiratory Health Survey, 15 668 persons aged 20-56 years underwent spirometry in 1991-1993 and 9 years later (n=8916). Risk of airway obstruction and lung function decline associated with smoking and early-onset (>10 years of age) and late-onset (<10 years of age) asthma were analysed with generalised estimating equation models and random-effect linear models, adjusting for covariates. Interaction of asthma with smoking was expressed as relative excess risk due to interaction (RERI). A 20-fold increase in adult airway obstruction was found among those with early-onset asthma independently of smoking status (never-smokers: OR 21.0, 95% CI 12.7-35; current smokers: OR 23.7, 95% CI 13.9-40.6). Late-onset asthma was associated with airway obstruction, with a stronger association among current smokers (OR 25.6, 95% CI 15.6-41.9) than among never-smokers (OR 11.2, 95% CI 6.8-18.6) (RERI 12.02, 95% CI 1.96-22.07). Stratifying by atopy, the association between smoking and asthma was most pronounced among nonatopics. Early- and late-onset asthma were associated with 10-20-fold increased risk of adult airway obstruction. Smoking increased the risk of adult airway obstruction in subjects with asthma onset after age 10 years. Investigation of measures potentially preventive of chronic obstructive pulmonary disease development following asthma is urgently needed.
Publisher Munksgaard
ISSN/ISBN 0903-1936
edoc-URL http://edoc.unibas.ch/dok/A6357855
Full Text on edoc No
Digital Object Identifier DOI 10.1183/09031936.00055514
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25431272
ISI-Number WOS:000350701200012
Document type (ISI) Journal Article
 
   

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23/06/2024