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TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development
Third-party funded project
Project title TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development
Principal Investigator(s) Pinschewer, Daniel
Organisation / Research unit Departement Biomedizin / Experimental Virology (Pinschewer)
Project start 01.01.2015
Probable end 31.12.2018
Status Completed
Abstract

This project aims to develop lymphocytic choriomeningitis virus-vectored vaccines against tuberculosis. Specifically the following work will be tackled:

  1. Generate lymphocytic choriomeningitis virus (LCMV) based vaccine vectors expressing immunodominant CD8 T cell antigens identified in latently infected individuals.
  2. Quantify and profile immune responses to these vaccine vectors in mice.
  3. A combination of the most immunogenic vectors will be assessed for the impact of massive CD8 T cell immunity on Mtb control, dissemination and latency in a mouse model.
Financed by Commission of the European Union
   

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29/03/2024