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The locus C11orf30 increases susceptibility to poly-sensitization
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2855436
Author(s) Amaral, A. F. S.; Minelli, C.; Guerra, S.; Wjst, M.; Probst-Hensch, N.; Pin, I.; Svanes, C.; Janson, C.; Heinrich, J.; Jarvis, D. L.
Author(s) at UniBasel Probst Hensch, Nicole
Year 2015
Title The locus C11orf30 increases susceptibility to poly-sensitization
Journal Allergy
Volume 70
Number 3
Pages / Article-Number 328-333
Keywords allergens, allergic sensitization, genes for atopy, poly-sensitization
Abstract

A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.

Publisher Munksgaard
ISSN/ISBN 0105-4538
edoc-URL http://edoc.unibas.ch/dok/A6348520
Full Text on edoc No
Digital Object Identifier DOI 10.1111/all.12557
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25546184
ISI-Number WOS:000349298100011
Document type (ISI) Article
 
   

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