Stereoselective, Catalytic Annulation Methods to Create Structurally Well-Defined Scaffolds
Third-party funded project
Project title Stereoselective, Catalytic Annulation Methods to Create Structurally Well-Defined Scaffolds
Principal Investigator(s) Sparr, Christof
Organisation / Research unit Departement Chemie / Organische Chemie (Sparr)
Project start 01.11.2015
Probable end 31.10.2020
Status Active
Abstract

Structurally well-defined objects are the elements required for the rational design of molecular backbones. The development of novel synthetic methods for the formation of new aromatic rings will provide unique scaffolds, which are not readily accessible otherwise. The catalyst controlled stereoselective arene-forming aldol condensation to form compounds with axial, helical or planar chirality will be investigated in detail. In the examined cascade reactions, the stereochemical information of small amine catalysts is transferred into new chirality elements leading to different, structurally distinct molecular architectures. The well-defined scaffolds will subsequently be employed to position various groups into a predictable spatial arrangement with respect to each other.

Financed by Swiss National Science Foundation (SNSF)
   

MCSS v5.8 PRO. 0.625 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
10/08/2020