A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 2845699
Author(s) Lepore, Marco; de Lalla, Claudia; Gundimeda, S. Ramanjaneyulu; Gsellinger, Heiko; Consonni, Michela; Garavaglia, Claudio; Sansano, Sebastiano; Piccolo, Francesco; Scelfo, Andrea; Häussinger, Daniel; Montagna, Daniela; Locatelli, Franco; Bonini, Chiara; Bondanza, Attilio; Forcina, Alessandra; Li, Zhiyuan; Ni, Guanghui; Ciceri, Fabio; Jenö, Paul; Xia, Chengfeng; Mori, Lucia; Dellabona, Paolo; Casorati, Giulia; De Libero, Gennaro
Author(s) at UniBasel De Libero, Gennaro
Häussinger, Daniel
Jenö, Paul
Year 2014
Title A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
Journal Journal of Experimental Medicine
Volume 211
Number 7
Pages / Article-Number 1360-1374

T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulated in leukemia cells. Primary acute myeloid and B cell acute leukemia blasts express CD1 molecules. mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immunodeficient mice against CD1c(+) human leukemia cells. The identification of immunogenic self-lipid antigens accumulated in leukemia cells and the observed leukemia control by lipid-specific T cells in vivo provide a new conceptual framework for leukemia immune surveillance and possible immunotherapy.

Publisher Rockefeller University Press
ISSN/ISBN 0022-1007
URL http://www.ncbi.nlm.nih.gov/pubmed/24935257
edoc-URL http://edoc.unibas.ch/dok/A6348326
Full Text on edoc Available
Digital Object Identifier DOI 10.1084/jem.20140410
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24935257
ISI-Number WOS:000338927200009
Document type (ISI) Article

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