A Chaperonin as Protein Nanoreactor for Atom Transfer Radical Polymerization
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2845422
Author(s) Renggli, Kasper; Nussbaumer, Martin G.; Urbani, Raphael; Pfohl, Thomas; Bruns, Nico
Author(s) at UniBasel Pfohl, Thomas
Renggli, Kasper
Nussbaumer, Martin
Urbani, Raphael
Bruns, Nico
Year 2014
Year: comment 2014
Title A Chaperonin as Protein Nanoreactor for Atom Transfer Radical Polymerization
Journal Angewandte Chemie
Volume 53
Number 5
Pages / Article-Number 1443-1447
Keywords chaperone proteins, controlled/living radical polymerization, nanoreactor, polymerization, thermosome
Abstract

The group II chaperonin thermosome (THS) from the archaea Thermoplasma acidophilum is reported as nanoreactor for atom-transfer radical polymerization (ATRP). A copper catalyst was entrapped into the THS to confine the polymerization into this protein cage. THS possesses pores that are wide enough to release polymers into solution. The nanoreactor favorably influenced the polymerization of N-isopropyl acrylamide and poly(ethylene glycol)methylether acrylate. Narrowly dispersed polymers with polydispersity indices (PDIs) down to 1.06 were obtained in the protein nanoreactor, while control reactions with a globular protein–catalyst conjugate only yielded polymers with PDIs above 1.84.

Publisher Verlag Chemie
ISSN/ISBN 0044-8249
edoc-URL http://edoc.unibas.ch/dok/A6348314
Full Text on edoc No
Digital Object Identifier DOI 10.1002/anie.201306798
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24459061
ISI-Number WOS:000336504500048
Document type (ISI) Article
 
   

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