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An Artificial Imine Reductase based on the Ribonuclease S Scaffold
Journal
ChemCatChem
Volume
6
Number
3
Pages / Article-Number
736-740
Keywords
asymmetric catalysis, half-sandwich complexes, metalloenzymes, reduction, transfer hydrogenation
Abstract
Dative anchoring of a piano-stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S-peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values for the synthesis of salsolidine.
