An Artificial Imine Reductase based on the Ribonuclease S Scaffold
Pages / Article-Number
asymmetric catalysis, half-sandwich complexes, metalloenzymes, reduction, transfer hydrogenation
Dative anchoring of a piano-stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S-peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values for the synthesis of salsolidine.