An Artificial Imine Reductase based on the Ribonuclease S Scaffold
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2839421
Author(s) Genz, Maika; Köhler, Valentin; Krauss, Michael; Singer, David; Hoffmann, Ralf; Ward, Thomas R.; Sträter, Norbert
Author(s) at UniBasel Köhler, Valentin
Ward, Thomas R.
Year 2014
Year: comment 2014
Title An Artificial Imine Reductase based on the Ribonuclease S Scaffold
Journal ChemCatChem
Volume 6
Number 3
Pages / Article-Number 736-740
Keywords asymmetric catalysis, half-sandwich complexes, metalloenzymes, reduction, transfer hydrogenation
Abstract

Dative anchoring of a piano-stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S-peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values for the synthesis of salsolidine.

Publisher Wiley
ISSN/ISBN 1867-3880 ; 1867-3899
edoc-URL http://edoc.unibas.ch/dok/A6338944
Full Text on edoc No
Digital Object Identifier DOI 10.1002/cctc.201300995
ISI-Number WOS:000332072300010
Document type (ISI) Article
 
   

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