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European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation : summary of ECIL-4 (2011)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
2833171
Author(s)
Matthes-Martin, S; Feuchtinger, T; Shaw, P J; Engelhard, D; Hirsch, H H; Cordonnier, C; Ljungman, P; Fourth European Conference on Infections in Leukemia
European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation : summary of ECIL-4 (2011)
Journal
Transplant infectious disease
Volume
14
Number
6
Pages / Article-Number
555-63
Keywords
human adenovirus, leukemia, stem cell, guidelines
Abstract
Human adenovirus (HAdV) infections are increasingly recognized as important pathogens in immunocompromised hosts, especially in patients with severely suppressed T-cell function. The 4th European Conference of Infections in Leukemia (ECIL-4) has developed evidence-based guidelines for diagnosis and management of HAdV infections. The risk for HAdV-associated disease is increased in children, and risk factors for HAdV disease are T-cell depletion, unrelated and cord blood hematopoietic stem cell transplantation, graft-versus-host disease grades III-IV, and lymphopenia. The recommended technique for monitoring of high-risk patients is quantitative polymerase chain reaction. Cidofovir is the most used antiviral therapy, although no controlled study has been performed. HAdV-specific T-cell therapy is in development.
