Asthma and COPD - The C/EBP Connection

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Asthma and COPD - The C/EBP Connection

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	2832666
Author(s)	Borger, Peter
Author(s) at UniBasel	Tamm, Michael Roth-Chiarello, Michael
Year	2012
Title	Asthma and COPD - The C/EBP Connection
Journal	The open respiratory medicine journal
Volume	6
Pages / Article-Number	1-13
Abstract	Asthma and chronic obstructive pulmonary disease (COPD) are the two most prominent chronic inflammatory lung diseases with increasing prevalence. Both diseases are associated with mild or severe remodeling of the airways. In this review, we postulate that the pathologies of asthma and COPD may result from inadequate responses and/or a deregulated balance of a group of cell differentiation regulating factors, the CCAAT/Enhancer Binding Proteins (C/EBPs). In addition, we will argue that the exposure to environmental factors, such as house dust mite and cigarette smoke, changes the response of C/EBPs and are different in diseased cells. These novel insights may lead to a better understanding of the etiology of the diseases and may provide new aspects for therapies.
Publisher	Bentham Open
ISSN/ISBN	1874-3064 (Electronic)
edoc-URL	http://edoc.unibas.ch/dok/A6338172
Full Text on edoc	No
Digital Object Identifier DOI	10.2174/1874306401206010001
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/22715349
ISI-Number	MEDLINE:22715349
Document type (ISI)	Journal Article

25/04/2024

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