Ascertaining in vivo virulence of Mycobacterium tuberculosis lineages in patients in Mbeya, Tanzania
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2820498
Author(s) Olaru, I D; Rachow, A; Lange, C; Ntinginya, N E; Reither, K; Hoelscher, M; Vollrath, O; Niemann, S
Author(s) at UniBasel Reither, Klaus
Year 2015
Title Ascertaining in vivo virulence of Mycobacterium tuberculosis lineages in patients in Mbeya, Tanzania
Journal The international journal of tuberculosis and lung disease
Volume 19
Number 1
Pages / Article-Number 70-3
Keywords CD4+count, diversity, HIV, strains, virulence
Abstract

We evaluated the relationship between the degree of immunodeficiency indicated by the number of circulating CD4+ T-cells and Mycobacterium tuberculosis lineages identified by spoligotyping and mycobacterial interspersed repetitive units-variable number of tandem repeats genotyping in human immunodeficiency virus (HIV) infected individuals with pulmonary tuberculosis from Mbeya, Tanzania. Of M. tuberculosis strains from 129 patients, respectively 55 (42.6%) and 37 (28.7%) belonged to Latin American Mediterranean and Delhi/Central-Asian lineages, while 37 (28.7%) patients were infected with other strains. There was no difference in the distribution of M. tuberculosis lineages among patients with early or advanced stages of HIV infection (P = 0.785), indicating that the virulence of strains from these lineages may not be substantially different in vivo.

Publisher IUATLD
ISSN/ISBN 1027-3719
edoc-URL http://edoc.unibas.ch/dok/A6337707
Full Text on edoc No
Digital Object Identifier DOI 10.5588/ijtld.14.0403
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25519793
ISI-Number WOS:000346893500013
Document type (ISI) Journal Article
 
   

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