Development and function of motor circuits
Third-party funded project
Project title Development and function of motor circuits
Principal Investigator(s) Arber, Silvia
Project Members Heindorf, Matthias
Neves Ferreira Pinto, Manuel
Ruder, Ludwig
Gunapala, Keith
Yang, Wuzhou
Organisation / Research unit Departement Biozentrum / Cell Biology (Arber),
Friedrich Miescher Institut FMI
Project Website http://p3.snf.ch/project-160339
Project start 01.04.2015
Probable end 31.03.2018
Status Completed
Abstract

The aim of our research is to unravel the organization and function of neuronal circuits controlling motor behavior. Movement is the common behavioral output of all CNS activity, yet how different movement patterns emerge and are regulated at the level of precisely connected neuronal circuits in an animal is currently poorly understood. In the BoE extension of my current SNF grant, we would like to exploit how motor output pathways orchestrate the precise control of motor output regulation in the spinal cord in intact animals, and how this process is influenced by sensory feedback circuits from muscles. This work lays the foundation for a research direction addressing how these identified neuronal circuit elements respond to spinal cord injury. We are convinced that together, these experiments will help to reveal general principles governing neuronal circuit organization at the level of identified neuronal subpopulations involved in motor control, as well as determine the factors influencing motor circuit reorganization after injury.

Keywords Neuronal circuits, Mouse genetics, Motor control
Financed by Swiss National Science Foundation (SNSF)
Follow-up project of 1121867 Assembly and function of motor circuits

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
3245574  Basaldella, Emanuela; Takeoka, Aya; Sigrist, Markus; Arber, Silvia  Multisensory Signaling Shapes Vestibulo-Motor Circuit Specificity  0092-8674  Cell  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3489263  Satoh, Daisuke; Pudenz, Christiane; Arber, Silvia  Context-Dependent Gait Choice Elicited by EphA4 Mutation in Lbx1 Spinal Interneurons  0896-6273  Neuron  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3564287  Tovote, Philip; Esposito, Maria Soledad; Botta, Paolo; Chaudun, Fabrice; Fadok, Jonathan P; Markovic, Milica; Wolff, Steffen B E; Ramakrishnan, Charu; Fenno, Lief; Deisseroth, Karl; Herry, Cyril; Arber, Silvia; Lüthi, Andreas  Midbrain circuits for defensive behaviour  0028-0836  Nature  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3692552  Ruder, Ludwig; Takeoka, Aya; Arber, Silvia  Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability  0896-6273 ; 1097-4199  Neuron  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3868672  Arber, Silvia  Organization and function of neuronal circuits controlling movement  1757-4676 ; 1757-4684  EMBO Molecular Medicine  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3957912  Wu, Jinjin; Capelli, Paolo; Bouvier, Julien; Goulding, Martyn; Arber, Silvia; Fortin, Gilles  A V0 core neuronal circuit for inspiration  2041-1723  Nature Communications  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3957925  Capelli, Paolo; Pivetta, Chiara; Soledad Esposito, Maria; Arber, Silvia  Locomotor speed control circuits in the caudal brainstem  0028-0836 ; 1476-4687  Nature  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
   

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11/12/2018