Potential impact of air pollution on multiple sclerosis in Tehran, Iran
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
2803579
Author(s)
Heydarpour, Pouria; Amini, Hassan; Khoshkish, Shayan; Seidkhani, Hossein; Sahraian, Mohammad Ali; Yunesian, Masud
Author(s) at UniBasel
Amini, Heresh
Year
2014
Title
Potential impact of air pollution on multiple sclerosis in Tehran, Iran
Journal
Neuroepidemiology
Volume
43
Number
3-4
Pages / Article-Number
233-8
Keywords
Air pollution, Iran, Multiple sclerosis, Particulate matter
Abstract
Background: Multiple sclerosis (MS) incidence has dramatically increased in Tehran, Iran. The health impact of air pollution in Tehran underscores the attention to a possible association to this environmental risk factor. In this study, the authors aimed to analyze the spatial distribution of prevalent MS cases and their association with the spatial patterns of air pollution. Methods: Patient records meeting McDonald's criteria for definite MS diagnosis with disease onset during 2003-2013 were obtained. Next, the location of 2,188 patients was successfully geo-referenced within Tehran metropolis by geographic information system (GIS) bureau of Iran's post office based on their phone numbers. A cluster analysis was performed using the average nearest neighbor index (ANNI) and quadrat analysis. The long-term exposures of MS patients to particulate matter (PM10), sulfur dioxide (SO2), nitrogen oxide (NO), nitrogen dioxide (NO2), and nitrogen oxides (NOx) were estimated using the previously developed land use regression models. Results: Prevalent MS cases had a clustered pattern in Tehran. A significant difference in exposure to PM10, SO2, NO2, and NOx (p > 0.001) was observed in MS cases compared with controls. Conclusion: This study revealed the potential role of long-term exposure to air pollutants as an environmental risk factor in MS. © 2014 S. Karger AG, Basel.
Publisher
Karger
ISSN/ISBN
0251-5350 ; 1423-0208
edoc-URL
http://edoc.unibas.ch/dok/A6329151
Full Text on edoc
Available
Digital Object Identifier DOI
10.1159/000368553
PubMed ID
http://www.ncbi.nlm.nih.gov/pubmed/25501708
ISI-Number
WOS:000346588400008
Document type (ISI)
Journal Article
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