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Asymptomatic malaria infections : detectability, transmissibility and public health relevance
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2780014
Author(s) Bousema, Teun; Okell, Lucy; Felger, Ingrid; Drakeley, Chris
Author(s) at UniBasel Felger, Ingrid
Year 2014
Title Asymptomatic malaria infections : detectability, transmissibility and public health relevance
Journal Nature Reviews Microbiology
Volume 12
Number 12
Pages / Article-Number 833-40
Abstract Most Plasmodium falciparum infections that are detected in community surveys are characterized by low-density parasitaemia and the absence of clinical symptoms. Molecular diagnostics have shown that this asymptomatic parasitic reservoir is more widespread than previously thought, even in low-endemic areas. In this Opinion article, we describe the detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes and for community interventions that aim at reducing transmission. We argue that wider deployment of molecular diagnostic tools is needed to provide adequate insight into the epidemiology of malaria and infection dynamics to aid elimination efforts.
Publisher Nature Publishing Group
ISSN/ISBN 1740-1526 ; 1740-1534
edoc-URL http://edoc.unibas.ch/dok/A6328883
Full Text on edoc No
Digital Object Identifier DOI 10.1038/nrmicro3364
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25329408
ISI-Number WOS:000345220700010
Document type (ISI) Review
 
   

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