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In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2742381
Author(s) Angliker, Nico; Rüegg, Markus A.
Author(s) at UniBasel Rüegg, Markus A.
Year 2013
Title In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons
Journal Bioarchitecture
Volume 3
Number 4
Pages / Article-Number 113-8
Abstract The mammalian target of rapamycin (mTOR) assembles into two distinct multi-protein complexes called mTORC1 and mTORC2. While mTORC1 controls the signaling pathways important for cell growth, the physiological function of mTORC2 is only partially known. Here we comment on recent work on gene-targeted mice lacking mTORC2 in the cerebellum or the hippocampus that provided strong evidence that mTORC2 plays an important role in neuron morphology and synapse function. We discuss that this phenotype might be based on the perturbed regulation of the actin cytoskeleton and the lack of activation of several PKC isoforms. The fact that PKC isoforms and their targets have been implicated in neurological disease including spinocerebellar ataxia and that they have been shown to affect learning and memory, suggests that aberration of mTORC2 signaling might be involved in diseases of the brain.
Publisher Taylor & Francis
ISSN/ISBN 1949-0992 ; 1949-100X
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201605/
edoc-URL http://edoc.unibas.ch/53456/
Full Text on edoc No
Digital Object Identifier DOI 10.4161/bioa.26497
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24721730
ISI-Number MEDLINE:24721730
Document type (ISI) Journal ArticleResearch Support, Non-U.S. Gov't
 
   

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