Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2700352
Author(s) Blüthgen, Nancy; Meili, Nicole; Chew, Geraldine; Odermatt, Alex; Fent, Karl
Author(s) at UniBasel Odermatt, Alex
Year 2014
Title Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio)
Journal Science of the Total Environment
Volume 476-477
Pages / Article-Number 207-17
Abstract Wide application of the UV-filter octocrylene (OC) in cosmetics leads to contamination of the aquatic environment, but effects of OC remain unclear. Here we determine bioaccumulation and molecular effects of OC. Adult male zebrafish were exposed to 22, 209 and 383 μg/L and embryos to 69, 293 and 925 μg/L OC. OC accumulated in fish up to 17 μg/g. Calculated BCF varied between 41 and 136. Microarray analysis in brain and liver following exposure to 383 μg/L OC revealed alteration of 628 and 136 transcripts, respectively. Most prominent GO processes included developmental processes, organ development, hematopoiesis, formation of blood vessels, blood circulation, fat cell differentiation and metabolism. Validation by RT-qPCR in brain and liver of adult fish and embryos included a series of genes. Blood levels of 11-ketotestosterone were not altered. The transcriptomics data suggest that OC mainly affects transcription of genes related to developmental processes in the brain and liver as well as metabolic processes in the liver.
Publisher Elsevier
ISSN/ISBN 0048-9697 ; 1879-1026
edoc-URL http://edoc.unibas.ch/50547/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.scitotenv.2014.01.015
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24463256
ISI-Number WOS:000333772500022
Document type (ISI) Journal Article
 
   

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