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Arterial blood pressure and long-term exposure to traffic-related air pollution : an analysis in the European study of cohorts for air pollution effects (ESCAPE)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 2698816
Author(s) Fuks, Kateryna B.; Weinmayr, Gudrun; Foraster, Maria; Dratva, Julia; Hampel, Regina; Houthuijs, Danny; Oftedal, Bente; Oudin, Anna; Panasevich, Sviatlana; Penell, Johanna; Sommar, Johan N.; Sørensen, Mette; Tiittanen, Pekka; Wolf, Kathrin; Xun, Wei W.; Aguilera, Inmaculada; Basagaña, Xavier; Beelen, Rob; Bots, Michiel L.; Brunekreef, Bert; Bueno-de-Mesquita, H. Bas; Caracciolo, Barbara; Cirach, Marta; de Faire, Ulf; de Nazelle, Audrey; Eeftens, Marloes; Elosua, Roberto; Erbel, Raimund; Forsberg, Bertil; Fratiglioni, Laura; Gaspoz, Jean-Michel; Hilding, Agneta; Jula, Antti; Korek, Michal; Krämer, Ursula; Künzli, Nino; Lanki, Timo; Leander, Karin; Magnusson, Patrik K. E.; Marrugat, Jaume; Nieuwenhuijsen, Mark J.; Ostenson, Claes-Göran; Pedersen, Nancy L.; Pershagen, Göran; Phuleria, Harish C.; Probst-Hensch, Nicole M.; Raaschou-Nielsen, Ole; Schaffner, Emmanuel; Schikowski, Tamara; Schindler, Christian; Schwarze, Per E.; Søgaard, Anne J.; Sugiri, Dorothea; Swart, Wim J. R.; Tsai, Ming-Yi; Turunen, Anu W.; Vineis, Paolo; Peters, Annette; Hoffmann, Barbara
Author(s) at UniBasel Dratva, Julia
Eeftens, Marloes
Künzli, Nino
Phuleria, Harish Chandra
Probst Hensch, Nicole
Schaffner, Emmanuel
Schikowski, Tamara
Schindler, Christian
Tsai, Ming-Yi
Year 2014
Title Arterial blood pressure and long-term exposure to traffic-related air pollution : an analysis in the European study of cohorts for air pollution effects (ESCAPE)
Journal Environmental Health Perspectives
Volume 122
Number 9
Pages / Article-Number 896-905
Abstract BACKGROUND: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific.OBJECTIVES: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hyper-tension in European populations.METHODS: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hyper-tension was defined as >= 140 mmHg systolic BP, or >= 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis.RESULTS: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles x m/day, respectively]. The estimated odds ratio (OR) for prevalent hyper-tension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles x m/day. Modeled air pollutants and BP were not clearly associated.CONCLUSIONS: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hyper-tension. The relationship of modeled air pollutants with BP was inconsistent.
Publisher National Institute of Environmental Health Sciences
ISSN/ISBN 0091-6765 ; 1552-9924
Full Text on edoc Available
Digital Object Identifier DOI 10.1289/ehp.1307725
PubMed ID
ISI-Number WOS:000341714600015
Document type (ISI) Journal Article

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