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Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2698788
Author(s) Adam, Martin; Imboden, Medea; Boes, Eva; Schaffner, Emmanuel; Künzli, Nino; Phuleria, Harish Chandra; Kronenberg, Florian; Gaspoz, Jean-Michel; Carballo, David; Probst-Hensch, Nicole
Author(s) at UniBasel Adam, Martin
Imboden, Medea
Schaffner, Emmanuel
Künzli, Nino
Phuleria, Harish Chandra
Probst Hensch, Nicole
Year 2014
Title Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability
Journal PLoS ONE
Volume 9
Number 8
Pages / Article-Number e104978
Mesh terms Aged; Autonomic Nervous System, metabolism; Cross-Sectional Studies; Electrocardiography; Female; Genotype; Heart Rate, drug effects; Humans; Interleukin-6, genetics; Male; Middle Aged; Particulate Matter, toxicity; Polymorphism, Genetic, genetics; Promoter Regions, Genetic, genetics
Abstract Exposure to particulate matter (PM) has been associated with an increase in many inflammatory markers, including interleukin 6 (IL6). Air pollution exposure has also been suggested to induce an imbalance in the autonomic nervous system (ANS), such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of polymorphisms in a major proinflammatory marker gene, interleukin 6 (IL6), on the relationship between long-term exposure to traffic-related PM10 (TPM10) and HRV.; For this cross-sectional study we analysed 1552 participants of the SAPALDIA cohort aged 50 years and older. Included were persons with valid genotype data, who underwent ambulatory 24-hr electrocardiogram monitoring, and reported on medical history and lifestyle. Main effects of annual average TPM10 and IL6 gene variants (rs1800795; rs2069827; rs2069840; rs10242595) on HRV indices and their interaction with average annual exposure to TPM10 were tested, applying a multivariable mixed linear model.; No overall association of TPM10 on HRV was found. Carriers of two proinflammatory G-alleles of the functional IL6 -174 G/C (rs1800795) polymorphism exhibited lower HRV. An inverse association between a 1 µg/m3 increment in yearly averaged TPM10 and HRV was restricted to GG genotypes at this locus with a standard deviation of normal-to-normal intervals (SDNN) (GG-carriers: -1.8%; 95% confidence interval -3.5 to 0.01; pinteraction(additive) = 0.028); and low frequency power (LF) (GG-carriers: -5.7%; 95%CI: -10.4 to -0.8; pinteraction(dominant) = 0.049).; Our results are consistent with the hypothesis that traffic-related air pollution decreases heart rate variability through inflammatory mechanisms.
Publisher Public Library of Science
ISSN/ISBN 1932-6203
edoc-URL http://edoc.unibas.ch/dok/A6298859
Full Text on edoc Available
Digital Object Identifier DOI 10.1371/journal.pone.0104978
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/25133672
ISI-Number WOS:000341302700058
Document type (ISI) Journal Article
 
   

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