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Effect of drug reminder packaging on medication adherence : a systematic review revealing research gaps
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 2681321
Author(s) Boeni, Fabienne; Spinatsch, Esther; Suter, Katja; Hersberger, Kurt E; Arnet, Isabelle
Author(s) at UniBasel Hersberger, Kurt
Arnet, Isabelle
Böni, Fabienne
Spinatsch, Esther
Suter-Zimmermann, Katja
Year 2014
Title Effect of drug reminder packaging on medication adherence : a systematic review revealing research gaps
Journal Systematic reviews
Volume 3
Pages / Article-Number 29

This was a systematic review of the literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Evidence mapping was used to reveal the effect of drug reminder packaging on medication adherence, to identify research gaps and to make suggestions for future research.; PubMed, Embase, CINAHL and PsycINFO were searched with an end date of September 2013 using the Medical Subject Headings (MeSH) term 'medication adherence' and 20 different search terms for 'drug reminder packaging', limited to the English and German languages. Additional references were identified through cross-referencing. All prospective controlled trials with an intervention using drug reminder packaging for patients taking at least one medication without the assistance of a health-care professional were included in the evidence mapping of the effect of drug reminder packaging on adherence and outcomes according to the Economic, Clinical and Humanistic Outcomes (ECHO) model.; A total of 30 studies met the inclusion criteria: 10 randomized controlled trials, 19 controlled clinical trials and 1 cohort study. Drug reminder packaging had a significant effect on at least one adherence parameter in 17 studies (57%). The methodological quality was strong in five studies. Two studies provided complete information. Clear research gaps emerged.; Overall, the studies showed a positive effect of drug reminder packaging on adherence and clinical outcomes. However, poor reporting and important gaps like missing humanistic and economic outcomes and neglected safety issues limit the drawing of firm conclusions. Suggestions are made for future research.

Publisher Biomed Central
ISSN/ISBN 2046-4053
Full Text on edoc No
Digital Object Identifier DOI 10.1186/2046-4053-3-29
PubMed ID
ISI-Number MEDLINE:24661495
Document type (ISI) Journal Article, Review

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