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Network of tangential pathways for neuronal migration in adult mammalian brain
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2635047
Author(s) Doetsch, Fiona; Alvarez-Buylla, A.
Author(s) at UniBasel Doetsch, Fiona
Year 1996
Title Network of tangential pathways for neuronal migration in adult mammalian brain
Journal Proceedings of the National Academy of Sciences of the United States of America
Volume 93
Number 25
Pages / Article-Number 14895-900
Abstract Cells in the brains of adult mammals continue to proliferate in the subventricular zone (SVZ) throughout the lateral wall of the lateral ventricle. Here we show, using whole mount dissections of this wall from adult mice, that the SVZ is organized as an extensive network of chains of neuronal precursors. These chains are immunopositive to the polysialylated form of NCAM, a molecule present at sites of plasticity, and TuJ1, an early neuronal marker. The majority of the chains are oriented along the rostrocaudal axis and many join the rostral migratory stream that terminates in the olfactory bulb. Using focal microinjections of DII and transplantation of SVZ cells carrying a neuron-specific reporter gene, we demonstrate that cells originating at different rostrocaudal levels of the SVZ migrate rostrally and reach the olfactory bulb where they differentiate into neurons. Our results reveal an extensive network of pathways for the tangential chain migration of neuronal precursors throughout the lateral wall of the lateral ventricle in the adult mammalian brain.
Publisher National Academy of Sciences
ISSN/ISBN 0027-8424 ; 1091-6490
edoc-URL http://edoc.unibas.ch/50374/
Full Text on edoc No
Digital Object Identifier DOI 10.1073/pnas.93.25.14895
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/8962152
ISI-Number WOS:A1996VY44800129
Document type (ISI) Journal Article
 
   

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