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A niche for adult neural stem cells
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2635020
Author(s) Doetsch, Fiona
Author(s) at UniBasel Doetsch, Fiona
Year 2003
Title A niche for adult neural stem cells
Journal Current Opinion in Genetics & Development
Volume 13
Number 5
Pages / Article-Number 543-550
Abstract The adult mammalian brain harbors multipotent stem cells, which reside and participate in specialized niches that support self-renewal and differentiation. The first cellular and molecular elements of the stem cell niche in the adult brain have been identified and include cell-cell interactions and somatic cell signaling, the vasculature, the extracellular matrix and basal lamina. Furthermore, regulation at the epigenetic level via chromatin modification and remodeling is an integral aspect of stem cell biology. Understanding the in vivo stem cell niche will provide a framework for the elucidation of stem cell function in the adult brain.
Publisher Elsevier
ISSN/ISBN 0959-437X ; 1879-0380
edoc-URL http://edoc.unibas.ch/50352/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.gde.2003.08.012
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/14550422
ISI-Number WOS:000186015100016
Document type (ISI) Review
 
   

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