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Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides.
Journal
Chemical Communications
Volume
50
Number
62
Pages / Article-Number
8499-502
Abstract
We describe a simple method for the direct modification of nucleobases in cyclic purine dinucleotides, important signalling molecules in both prokaryotes and eukaryotes. The method tolerates all members of the cyclic dinucleotide family and could be used to modulate their function or introduce useful side-chains such as fluorophores and photo-crosslinking groups.
