Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Buch. ex Benth. (Lamiaceae)
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 2570813
Author(s) Mokoka, Tsholofelo A.; Peter, Xolani K.; Fouche, Gerda; Moodley, Nivan; Adams, Michael; Hamburger, Matthias; Kaiser, Marcel; Brun, Reto; Maharaj, Vinesh; Koorbanally, Neil
Author(s) at UniBasel Kaiser, Marcel
Brun, Reto
Hamburger, Matthias
Year 2014
Title Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Buch. ex Benth. (Lamiaceae)
Journal South African journal of botany
Volume 90
Pages 93-95
Keywords Antileishmanial activity, Salvia repens, Leishmania donovani, 12-Methoxycarnosic acid, Abietane diterpene, HPLC profiling
Abstract In South Africa, Salvia repens is used traditionally to treat sores, stomach ache and diarrhoea. The high performance liquid chromatography (HPLC)-based activity profiling of S. repens whole plant extract showed an active abietane diterpene, identified as 12-methoxycamosic acid (1) which showed antiprotozoal activity against axenically grown Leishmania donovani amastigotes with an IC50 of 0.75 mu M with marginal cytotoxicity against the L6-cells (IC50, 17.3 mu M). (C) 2013 SAAB. Published by Elsevier B.V. All rights reserved.
Publisher Elsevier
ISSN/ISBN 0254-6299
edoc-URL http://edoc.unibas.ch/dok/A6205307
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.sajb.2013.10.014
ISI-Number WOS:000331672400011
Document type (ISI) Article
 
   

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