4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 2557832
Author(s) Weis, R; Seebacher, W; Brun, R; Kaiser, M; Saf, R; Faist, J
Author(s) at UniBasel Brun, Reto
Kaiser, Marcel
Year 2014
Title 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity
Journal Monatshefte für Chemie
Volume 145
Number 2
Pages / Article-Number 311-317

A new series of 4-aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates have been prepared. Their activities against the multiresistant K-1 strain of Plasmodium falciparum and Trypanosoma brucei rhodesiense were determined and compared with the results for ethanoate and propanoate analogs. Several structure-activity relationships were detected. The antiprotozoal activities were influenced by the kind of both amino substituents and by the chain length of the acid moiety. The butanoates exhibited higher antiplasmodial potency than their analogs with shorter chain length. Representative compounds of the propanoate and butanoate series were the most active antitrypanosomal compounds

Publisher Springer
ISSN/ISBN 0026-9247
edoc-URL http://edoc.unibas.ch/dok/A6263110
Full Text on edoc No
Digital Object Identifier DOI 10.1007/s00706-013-1116-2

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