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Serum bilirubin is associated with lung function in a Swiss general population sample
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 2553272
Author(s) Curjuric, Ivan; Imboden, Medea; Adam, Martin; Bettschart, Robert W.; Gerbase, Margaret W.; Künzli, Nino; Rochat, Thierry; Rohrer, Lucia; Rothe, Thomas B.; Schwartz, Joel; Stolz, Daiana; Tschopp, Jean-Marie; von Eckardstein, Arnold; Kronenberg, Florian; Probst-Hensch, Nicole M.
Author(s) at UniBasel Curjuric, Ivan
Imboden, Medea
Adam, Martin
Künzli, Nino
Probst Hensch, Nicole
Year 2014
Title Serum bilirubin is associated with lung function in a Swiss general population sample
Journal The European respiratory journal
Volume 43
Number 5
Pages / Article-Number 1278-88
Mesh terms Adolescent; Adult; Bilirubin, blood; Biomarkers, blood; Body Mass Index; Cohort Studies; Female; Forced Expiratory Volume; Genotype; Humans; Linear Models; Lung, physiopathology; Male; Middle Aged; Respiration Disorders, physiopathology; Respiratory Function Tests; Smoking, adverse effects; Spirometry; Switzerland; Vital Capacity; Young Adult
Abstract Bilirubin is a strong antioxidant. Increased serum levels have been associated with lower respiratory disease and mortality risk. We studied the association of bilirubin with lung function in the Swiss study on Air Pollution and Lung Disease in adults (SAPALDIA) cohort. Associations between natural logarithmised bilirubin and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and mean forced expiratory flow between 25%-75% of FVC (FEF25-75%) were tested using multiple linear regression in the whole study population (n=4195) and strata of ever-smoking and high body mass index (BMI, defined by the highest distribution quartile). Associations were retested with single nucleotide polymorphism rs6742078, a genetic determinant of bilirubin. High bilirubin levels were significantly associated with higher FEV1/FVC and FEF25-75% overall. Upon stratification, significant associations persisted in ever-smokers, amounting to 1.1% (95% CI 0.1-2.2%) increase in FEV1/FVC, and 116.2 mL·s(-1) (95% CI -15.9-248.4 mL·s(-1)) in FEF25-75% per interquartile range of bilirubin exposure in smokers with high BMI. Associations were positive but nonsignificant in never-smokers with high BMI. Similarly, rs6742078 genotype TT was associated with increased FEV1/FVC and FEF25-75%. Our results suggest a possible protective role of bilirubin on lung tissue, which could be important for prevention and therapy.
Publisher Munksgaard
ISSN/ISBN 0903-1936
Full Text on edoc No
Digital Object Identifier DOI 10.1183/09031936.00055813
PubMed ID
ISI-Number WOS:000335614600012
Document type (ISI) Journal Article

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