It is planned to expand the approach of clip stabilization to develop a novel
approach of surface supramolecular engineering. It is based on the use of macrocyclic amphiphiles
bearing several (2-8) metal coordination ligands at their polar side. The building blocks will be
produced by chemically “decorating” calixarene macrocycles, a class of molecules widely used to
produce designer amphiphiles.4 In ORACLE, the work will consist in introducing in the calixarene
macrocycle, chemical moieties possessing the ability of coordinating the chosen metal ions, e.g.
carboxylate, pyridine, terpyridine.