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A study on the epidemiology of stevens-johnson syndrome and toxic epidermal necrolysis
Third-party funded project
Project title A study on the epidemiology of stevens-johnson syndrome and toxic epidermal necrolysis
Principal Investigator(s) Spöndlin, Julia
Co-Investigator(s) Meier, Christoph R.
Bircher, Andreas J.
Frey, Noel
Bodmer, Michael
Marxer, Carole
Organisation / Research unit Bereich Querschnittsfächer (Klinik) / Spitalpharmazie (Meier),
Departement Pharmazeutische Wissenschaften / Clinical Pharmacy (Meier)
Project start 01.07.2014
Probable end 31.12.2015
Status Completed
Abstract

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe cutaneous adverse drug reactions. Due to the rare nature of SJS/TEN, available evidence on the frequency of these diseases and on the role of a potential causal involvement of drugs is scarce. Some hospital based studies provide evidence on a possible role of certain drugs, but further evidence is needed, as SJS/TEN treatment is mainly based on discontinuation of suspected drugs. Previously published incidence rates (IRs) are scarce and vary greatly due to the low numbers of patients studied and due to difficulties in defining the population at risk. In addition, follow-up data on mortality and especially on long-term complications in survivors of SJS/TEN are sparse. The planned epidemiological study will include a case-control part identifying drugs which have been taken at the time of the onset of SJS/TEN, as well as two different cohort studies. In the first cohort study we will assess IRs of SJS/TEN overall as well as in new users of different drugs. In the second cohort analysis we will quantify mortality rates and identify long-term complications of SJS/TEN applying a Cox proportional hazard analysis. The suggested project will involve one of the largest SJS/TEN study populations available, and will be among the first SJS/TEN studies using a large longitudinal database (first one on the Clinical Practice Research Datalink - CPRD).

Keywords stevens-johnson syndrome, pharmacoepidemiology, clinical practice research database, drug hypersensitivity
Financed by University of Basel

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
3703325  Frey, Noel; Bircher, Andreas; Bodmer, Michael; Jick, Susan S.; Meier, Christoph R.; Spoendlin, Julia  Validation of Stevens-Johnson syndrome or toxic epidermal necrolysis diagnoses in the Clinical Practice Research Datalink  1053-8569 ; 1099-1557  Pharmacoepidemiology and Drug Safety  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3846410  Frey, Noel; Jossy, Janine; Bodmer, Michael; Jick, Susan S.; Meier, Christoph R.; Spoendlin, Julia  The Epidemiology of Stevnes-Johnson Syndrome and Toxic Epidermal Necrolysis in the UK  0022-202X ; 1523-1747  Journal of Investigative Dermatology  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4215817  Frey, Noel; Bircher, Andreas; Bodmer, Michael; Jick, Susan S; Meier, Christoph R; Spoendlin, Julia  Antibiotic drug use and the risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis A Population-Based Case-Control Study.  0022-202X  The Journal of investigative dermatology  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4215818  Frey, Noel; Bodmer, Michael; Bircher, Andreas; Rüegg, Stephan; Jick, Susan S.; Meier, Christoph R.; Spoendlin, Julia  The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs  0013-9580 ; 1528-1167  Epilepsia  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4617931  Marxer, Carole A.; Frey, Noel; Bodmer, Michael; Bircher, Andreas J.; Jick, Susan S.; Meier, Christoph R.; Spoendlin, Julia  Survival after Stevens‒Johnson Syndrome or Toxic Epidermal Necrolysis: A United Kingdom‒Based Cohort Study  0022-202X ; 1523-1747  Journal of Investigative Dermatology  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
   

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21/06/2024