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A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2440667
Author(s) Faraone, Stephen V.
Author(s) at UniBasel Steinhausen, Hans-Christoph
Year 2011
Title A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings
Journal Biological psychiatry
Volume 70
Number 3
Pages / Article-Number 230-6
Keywords 5-HTTLPR (SLC6A4), attention-deficit/hyperactivity disorder, DAT1 (SLC6A3), delay aversion, impulsivity
Abstract Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotonin-regulating genes.; Impulsive drive for immediate reward and delay aversion were measured in 459 male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonin-transporter-linked polymorphic region polymorphism and a DAT1 (SLC6A3) 40-base pair variable number tandem repeat located in the 3'-untranslated region of the gene.; There was no effect of dopamine transporter (DAT)1 on IDIR. As predicted, serotonin-transporter-linked polymorphic region s-allele carriers were more delay averse. This effect was driven by the s/l genotype in the ADHD group. These results were not altered by taking account of the rs25531 A/G single nucleotide polymorphism and were independent of age, IQ, and oppositional defiant disorder symptoms.; The results support the genetic distinctiveness of IDIR and delay aversion in ADHD and implicate serotonin function in delay aversion. Possible explanations of the heterosis effect in the ADHD cases are presented.
Publisher Elsevier
ISSN/ISBN 0006-3223
edoc-URL http://edoc.unibas.ch/dok/A6243546
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.biopsych.2011.01.040
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21497794
ISI-Number WOS:000292633600006
Document type (ISI) Journal Article
 
   

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