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SyNeurOut - Synthesis of (2R)-Hydroxy-Norneomajucin and Biological Evaluation of Neurite Outgrowth
Third-party funded project |
Project title |
SyNeurOut - Synthesis of (2R)-Hydroxy-Norneomajucin and Biological Evaluation of Neurite Outgrowth |
Principal Investigator(s) |
Gademann, Karl
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Organisation / Research unit |
Departement Chemie / Organische Chemie (Gademann) |
Project start |
01.03.2014 |
Probable end |
29.02.2016 |
Status |
Completed |
Abstract |
Over the past century, there has been a worldwide escalation in the prevalence of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and Huntington’s disease. There are still no cures for these disorders and current therapeutics are only palliative. More recently, emerging therapeutic approaches have focused on maintaining neuronal function in these disease models with small molecules that possess neurotrophic properties. In this multidisciplinary proposal, we plan to complete the first total synthesis of (2R)-hydroxy-norneomajucin, confirm the neurotrophic activity of this natural product and evaluate advanced intermediates, and also initiate investigations into the biological target of this compound.
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Financed by |
Commission of the European Union
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14/05/2024
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