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Ambient air pollution : a cause of COPD?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2384309
Author(s) Schikowski, Tamara; Mills, Inga C.; Anderson, H. Ross; Cohen, Aaron; Hansell, Anna; Kauffmann, Francine; Krämer, Ursula; Marcon, Alessandro; Perez, Laura; Sunyer, Jordi; Probst-Hensch, Nicole; Künzli, Nino
Author(s) at UniBasel Schikowski, Tamara
Probst Hensch, Nicole
Künzli, Nino
Year 2014
Title Ambient air pollution : a cause of COPD?
Journal The European respiratory journal
Volume 43
Number 1
Pages / Article-Number 250-263
Mesh terms Air Pollution, statistics & numerical data; Causality; Environmental Exposure, statistics & numerical data; Humans; Nitrogen Dioxide; Ozone; Particulate Matter; Pulmonary Disease, Chronic Obstructive, epidemiology; Vehicle Emissions
Abstract The role of ambient air pollution in the development of chronic obstructive pulmonary disease (COPD) is considered to be uncertain. We review the evidence in the light of recent studies. Eight morbidity and six mortality studies were identified. These were heterogeneous in design, characterisation of exposure to air pollution and methods of outcome definition. Six morbidity studies with objectively defined COPD (forced expiratory volume in 1 s/forced vital capacity ratio) were cross-sectional analyses. One longitudinal study defined incidence of COPD as the first hospitalisation due to COPD. However, neither mortality nor hospitalisation studies can unambiguously distinguish acute from long-term effects on the development of the underlying pathophysiological changes. Most studies were based on within-community exposure contrasts, which mainly assess traffic-related air pollution. Overall, evidence of chronic effects of air pollution on the prevalence and incidence of COPD among adults was suggestive but not conclusive, despite plausible biological mechanisms and good evidence that air pollution affects lung development in childhood and triggers exacerbations in COPD patients. To fully integrate this evidence in the assessment, the life-time course of COPD should be better defined. Larger studies with longer follow-up periods, specific definitions of COPD phenotypes, and more refined and source-specific exposure assessments are needed.
Publisher Munksgaard
ISSN/ISBN 0903-1936
edoc-URL http://edoc.unibas.ch/dok/A6233669
Full Text on edoc No
Digital Object Identifier DOI 10.1183/09031936.00100112
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/23471349
ISI-Number WOS:000329552200031
Document type (ISI) Review
 
   

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