Activity of diimidazoline amides against African trypanosomiasis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2381206
Author(s) Dong, Yuxiang; Wang, Xiaofang; Cal, Monica; Kaiser, Marcel; Vennerstrom, Jonathan L
Author(s) at UniBasel Kaiser, Marcel
Year 2014
Title Activity of diimidazoline amides against African trypanosomiasis
Journal Bioorganic & medicinal chemistry letters
Volume 24
Number 3
Pages / Article-Number 944-8
Keywords Diimidazoline, African trypanosomiasis, Trypanosoma brucei rhodesiense
Abstract

We identified several diimidazoline mono- and diamides that were as potent as pentamidine against Trypanosoma brucei rhodesiense in vitro. All of these were also less cytotoxic than pentamidine, but none was as effective as the latter in a T. brucei rhodesiense-infected mouse model. A single imidazoline may be sufficient for high antitrypanosomal activity provided that a second weak base functional group is present.

Publisher Elsevier
ISSN/ISBN 0960-894X
edoc-URL http://edoc.unibas.ch/dok/A6233626
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.bmcl.2013.12.064
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24398295
ISI-Number WOS:000330120800044
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.637 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
08/08/2020