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Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2380606
Author(s) Orhan, Ilkay Erdogan; Sener, Bilge; Kaiser, Marcel; Brun, Reto; Tasdemir, Deniz
Author(s) at UniBasel Kaiser, Marcel
Brun, Reto
Year 2014
Title Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts
Journal Turkish journal of biochemistry
Volume 38
Number 4
Pages / Article-Number 403-408
Keywords Lycopodium, Lycopodiaceae, antiprotozoal activity, cytotoxicity
Abstract Objective: We assessed in vitro antiprotozoal activity of the petroleum ether (PE), chloroform (CHCl3), methanol (MeOH) and alkaloid (ALK) extracts of the ferns Lycopodium clavatum L. (LC) and L. complanatum L. subsp. chamaecyparissus (A. Br.) Doll. (LCC).Methods: Antiprotozoal activity of the extracts was assessed against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum and their cytotoxicity was tested on rat skeletal myoblast (L6) cells.Results: All extracts inhibited the growth of T. brucei rhodesiense with IC50 values of 9.3 to 47.0 mu g/ml. The LC-CHCl3 extract had the best trypanocidal activity against T. cruzi (IC50 15.3 mu g/ml), whereas the LCC-PE extract displayed the highest antileishmanial activity (IC50 4.5 mu g/ml). The most potent activity against P. falciparum was exhibited by LCC-ALK (IC50 2.7 mu g/ml) and LCC-PE (IC50 2.8 mu g/ml) extracts. No cytotoxicity for any of the extracts was detected at the highest concentration tested (IC50 > 90 mu g/ml).Conclusion: Both fern species possibly contain antiprotozoal compounds with no cytotoxicity.
Publisher Turkish Biochemical Society]
edoc-URL http://edoc.unibas.ch/dok/A6223632
Full Text on edoc No
Digital Object Identifier DOI 10.5505/tjb.2013.07379
ISI-Number WOS:000329577500006
Document type (ISI) Article
 
   

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