A synthetic nanomaterial for virus recognition produced by surface imprinting
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 2359502
Author(s) Cumbo, Alessandro; Lorber, Bernard; Corvini, Philippe F-X; Meier, Wolfgang; Shahgaldian, Patrick
Author(s) at UniBasel Meier, Wolfgang P.
Year 2013
Title A synthetic nanomaterial for virus recognition produced by surface imprinting
Journal Nature Communications
Volume 4
Pages / Article-Number 1503
Abstract Major stumbling blocks in the production of fully synthetic materials designed to feature virus recognition properties are that the target is large and its self-assembled architecture is fragile. Here we describe a synthetic strategy to produce organic/inorganic nanoparticulate hybrids that recognize non-enveloped icosahedral viruses in water at concentrations down to the picomolar range. We demonstrate that these systems bind a virus that, in turn, acts as a template during the nanomaterial synthesis. These virus imprinted particles then display remarkable selectivity and affinity. The reported method, which is based on surface imprinting using silica nanoparticles that act as a carrier material and organosilanes serving as biomimetic building blocks, goes beyond simple shape imprinting. We demonstrate the formation of a chemical imprint, comparable to the formation of biosilica, due to the template effect of the virion surface on the synthesis of the recognition material.
Publisher Nature Publishing Group
ISSN/ISBN 2041-1723
edoc-URL http://edoc.unibas.ch/50016/
Full Text on edoc No
Digital Object Identifier DOI 10.1038/ncomms2529
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/23422671
ISI-Number WOS:000316616400073
Document type (ISI) Journal Article

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