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Acoustic factors govern developmental sharpening of spatial tuning in the auditory cortex
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2262034
Author(s) Mrsic-Flogel, Thomas D.; Schnupp, Jan W. H.; King, Andrew J.
Author(s) at UniBasel Mrsic-Flogel, Thomas
Year 2003
Title Acoustic factors govern developmental sharpening of spatial tuning in the auditory cortex
Journal Nature Neuroscience
Volume 6
Number 9
Pages / Article-Number 981-8
Abstract Auditory localization relies on the detection and interpretation of acoustic cues that change in value as the head and external ears grow. Here we show that the maturation of these structures is an important determinant for the development of spatial selectivity in the ferret auditory cortex. Spatial response fields (SRFs) of high-frequency cortical neurons recorded at postnatal days (P) 33-39 were broader, and transmitted less information about stimulus direction, than in older ferrets. They also exhibited slightly broader frequency tuning than neurons recorded in adult animals. However, when infant neurons were stimulated through virtual ears of adults, SRFs sharpened significantly and the amount of transmitted information increased. This improvement was predicted by a model that generates SRF shape from the localization cue values and the neurons' binaural spectrotemporal response properties. The maturation of spatial response characteristics in auditory cortex therefore seems to be limited by peripheral rather than by central factors.
Publisher Nature America
ISSN/ISBN 1097-6256 ; 1546-1726
edoc-URL http://edoc.unibas.ch/49658/
Full Text on edoc No
Digital Object Identifier DOI 10.1038/nn1108
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/12910241
ISI-Number WOS:000184970400018
Document type (ISI) Journal Article
 
   

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