Assessment of dual life stage antiplasmodial activity of british seaweeds
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 2230430
Author(s) Spavieri, Jasmine; Allmendinger, Andrea; Kaiser, Marcel; Itoe, Maurice Ayamba; Blunden, Gerald; Mota, Maria M; Tasdemir, Deniz
Author(s) at UniBasel Kaiser, Marcel
Year 2013
Title Assessment of dual life stage antiplasmodial activity of british seaweeds
Journal Marine drugs
Volume 11
Number 10
Pages / Article-Number 4019-34
Keywords seaweed, marine alga, malaria, Plasmodium, malaria prophylaxis, fatty acid biosynthesis, liver stage, blood stage
Abstract

Terrestrial plants have proven to be a prolific producer of clinically effective antimalarial drugs, but the antimalarial potential of seaweeds has been little explored. The main aim of this study was to assess the in vitro chemotherapeutical and prophylactic potential of the extracts of twenty-three seaweeds collected from the south coast of England against blood stage (BS) and liver stage (LS) Plasmodium parasites. The majority (14) of the extracts were active against BS of P. falciparum, with brown seaweeds Cystoseira tamariscifolia, C. baccata and the green seaweed Ulva lactuca being the most active (IC50s around 3 μg/mL). The extracts generally had high selectivity indices (>10). Eight seaweed extracts inhibited the growth of LS parasites of P. berghei without any obvious effect on the viability of the human hepatoma (Huh7) cells, and the highest potential was exerted by U. lactuca and red seaweeds Ceramium virgatum and Halopitys incurvus (IC50 values 14.9 to 28.8 μg/mL). The LS-active extracts inhibited one or more key enzymes of the malarial type-II fatty acid biosynthesis (FAS-II) pathway, a drug target specific for LS. Except for the red seaweed Halopitys incurvus, all LS-active extracts showed dual activity versus both malarial intracellular stage parasites. This is the first report of LS antiplasmodial activity and dual stage inhibitory potential of seaweeds.

Publisher MDPI AG
ISSN/ISBN 1660-3397
edoc-URL http://edoc.unibas.ch/dok/A6194586
Full Text on edoc No
Digital Object Identifier DOI 10.3390/md11104019
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24152562
ISI-Number WOS:000328622500024
Document type (ISI) Article
 
   

MCSS v5.8 PRO. 0.429 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
07/08/2020