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Atherogenesis in youth : early consequence of adolescent smoking
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 2184868
Author(s) Dratva, Julia; Probst-Hensch, Nicole; Schmidt-Trucksäss, Arno; Caviezel, Seraina; de Groot, Eric; Bettschart, Robert; Saleh, Lanja; Gapoz, Jean-Michel; Rothe, Thomas; Schindler, Christian; Stolz, Daiana; Turk, Alexander; Rochat, Thierry; Kuenzli, Nino; Zemp, Elisabeth
Author(s) at UniBasel Dratva, Julia
Probst Hensch, Nicole
Künzli, Nino
Schindler, Christian
Zemp Stutz, Elisabeth
Year 2013
Title Atherogenesis in youth : early consequence of adolescent smoking
Journal Atherosclerosis
Volume 230
Number 2
Pages / Article-Number 304-9
Keywords Adolescence, Atherosclerosis, Epidemiology, Carotid intima media thickness, Risk factors smoking

Cigarette smoking is a prevalent risk behavior among adolescents and tracks into adulthood. Little is known on the early impact of smoking on the vasculature in adolescence, although smoking is considered highly atherogenic in adults. We investigated the association between active smoking and Carotid artery Intima Media Thickness (CIMT), an early indicator of atherosclerosis.; The SAPALDIA Youth Study is a nested study involving 356 offspring (8-20 yrs) of the Swiss SAPALDIA cohort who reported on early life, health and lifestyle, smoking habits and disease history. 288 youth underwent clinical examination. Mean average and maximum CIMT were calculated across all images of right and left common carotid. Multi-level linear regression was performed with weekly smoking, daily number of cigarettes and serum cotinine, adjusting for participant's and parental confounders. Valid CIMT data was available in 275 offspring (mean age 15 yrs, 53% girls). Weekly smoking was reported by 10% and current parental smoking by 24%. Individual mean and maximal CIMT averaged to 0.52 mm (sd 0.05) and 0.60 mm (sd. 0.05), respectively. Regression analyses yielded significant increase in average CIMT (mm) in weekly smokers (0.025, 95% CI 0.006; 0.045), per cigarette/day (0.003, 95% CI 0.001; 0.005) and serum cotinine level (0.008/100 μg/l, 95% CI 0.002; 0.015), which remained consistent after adjusting for parental confounders.; Our study yields evidence of an early adverse impact of active tobacco exposure on atherogenesis in adolescents, independent of parental smoking, underlining the public health importance of prevention of adolescent smoking.

Publisher Elsevier
ISSN/ISBN 0021-9150
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.atherosclerosis.2013.08.004
PubMed ID
ISI-Number WOS:000324747800023
Document type (ISI) Article

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