Birth weight and carotid artery intima-media thickness
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1970529
Author(s) Dratva, Julia; Breton, Carrie V; Hodis, Howard N; Mack, Wendy J; Salam, Muhammad T; Zemp, Elisabeth; Gilliland, Frank; Kuenzli, Nino; Avol, Ed
Author(s) at UniBasel Zemp Stutz, Elisabeth
Dratva, Julia
Künzli, Nino
Year 2013
Title Birth weight and carotid artery intima-media thickness
Journal Journal of pediatrics
Volume 162
Number 5
Pages / Article-Number 906-11.e1-2
Abstract

To determine the association between birth weight and carotid artery intima-media thickness (CIMT), a measure of atherogenesis, in a population of 11-year-old children.; CIMT measured by high-resolution ultrasound, and birth registry data were available for 670 children of the Southern California Children's Health Study. Multivariate regression analyses were performed to investigate the association between birth weight and CIMT, with adjustment for child's health status and lifestyle, pregnancy information, and parental health.; Mean CIMT was 0.57 mm (SD 0.04). We found a nonlinear association between birth weight and CIMT, with an increase in CIMT of 0.014 mm in the fifth (P value .01) compared with the third birth weight quintile. These associations were robust in subsample analyses in children considered normal-weight by gestational age or in term-born children. No significant association with CIMT was found for the lowest quintile.; Greater birth weight was significantly associated with increased CIMT at age 11 years. No evidence for an impact of lower birth weight was found. The predictive value of childhood CIMT on future cardiovascular outcomes is largely unknown, but strong associations between childhood cardiovascular disease risk factors and adult vascular disease suggest that increased CIMT in childhood may be clinically important.

Publisher Mosby
ISSN/ISBN 0022-3476
edoc-URL http://edoc.unibas.ch/dok/A6146295
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jpeds.2012.10.060
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/23260106
ISI-Number WOS:000317836300009
Document type (ISI) Journal Article
 
   

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04/12/2022