Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Neue genetische Tests und ihr Nutzen in der Krebsvorsorge
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1776454
Author(s) Probst-Hensch, Nicole M; Brand, Angela
Author(s) at UniBasel Probst Hensch, Nicole
Year 2013
Title Neue genetische Tests und ihr Nutzen in der Krebsvorsorge
Journal Therapeutische Umschau
Volume 70
Number 4
Pages / Article-Number 251-4; discussion 255-6
Abstract

The promises resulting from the decoding of the human genome have not been fulfilled to the extent as expected. At the same time it is fair to say that the results of recent genetic research have not been useless. In the area of familial cancer the clinical benefit of genetic testing for healthy family members is very convincing, where the risk of disease can be reduced substantially through preventive interventions. For example, prophylactic mastectomy and premenopausal ovariectomy can reduce the cancer risk in carriers of BRCA1 and BRCA2 mutations dramatically. In recent years, the research has moved towards the decoding of the genetic causes of sporadic cancers as well. Genome-wide and hypothesis-free association studies have linked different chromosome regions to cancer. By this, new insights into disease mechanisms could be gained, an important requirement for the development of diagnostics and drugs. However, what is missing is the evidence that the associated SNPs (Single Nucleotide Polymorphisms) could be useful for individual risk calculation or for stratification of the population into groups with different preventive or screening needs

Publisher Hans Huber
ISSN/ISBN 0040-5930
URL http://www.ncbi.nlm.nih.gov/pubmed/23535553
edoc-URL http://edoc.unibas.ch/dok/A6124606
Full Text on edoc No
Digital Object Identifier DOI 10.1024/0040-5930/a000397
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/23535553
ISI-Number MEDLINE:23535553
Document type (ISI) English AbstractJournal ArticleReview
 
   

MCSS v5.8 PRO. 0.373 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
29/02/2024