A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1766586
Author(s) Zhang, Ruyang; Zhao, Yang; Chu, Minjie; Mehta, Amar; Wei, Yongyue; Liu, Yao; Xun, Pengcheng; Bai, Jianling; Yu, Hao; Su, Li; Zhang, Hongxi; Hu, Zhibin; Shen, Hongbing; Chen, Feng; Christiani, David C.
Author(s) at UniBasel Mehta, Amar
Year 2013
Title A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure
Journal PLoS ONE
Volume Vol. 8, H. 3 , e59035
Abstract Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood.; We aimed to identify single nucleotide polymorphisms (SNPs) that are associated with the rate of forced expiratory volume in one second (FEV1) decline by a large scale genetic association study in newly-hired healthy young female cotton textile workers.; DNA samples were genotyped using the Illumina Human CVD BeadChip. Change rate in FEV1 was modeled as a function of each SNP genotype in linear regression model with covariate adjustment. We controlled the type 1 error in study-wide level by permutation method. The false discovery rate (FDR) and the family-wise error rate (FWER) were set to be 0.10 and 0.15 respectively.; Two SNPs were found to be significant (P>6.29×10(-5)), including rs1910047 (P = 3.07×10(-5), FDR = 0.0778) and rs9469089 (P = 6.19×10(-5), FDR = 0.0967), as well as other eight suggestive (P>5×10(-4)) associated SNPs. Gene-gene and gene-environment interactions were also observed, such as rs1910047 and rs1049970 (P = 0.0418, FDR = 0.0895); rs9469089 and age (P = 0.0161, FDR = 0.0264). Genetic risk score analysis showed that the more risk loci the subjects carried, the larger the rate of FEV1 decline occurred (P trend = 3.01×10(-18)). However, the association was different among age subgroups (P = 7.11×10(-6)) and endotoxin subgroups (P = 1.08×10(-2)). Functional network analysis illustrates potential biological connections of all interacted genes.; Genetic variants together with environmental factors interact to affect the rate of FEV1 decline in cotton textile workers.
Publisher Public Library of Science
ISSN/ISBN 1932-6203
edoc-URL http://edoc.unibas.ch/dok/A6124550
Full Text on edoc No
Digital Object Identifier DOI 10.1371/journal.pone.0059035
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/23527081
Document type (ISI) Journal Article
 
   

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