Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 171613
Author(s) Mombereau, Cedric; Kaupmann, Klemens; Gassmann, Martin; Bettler, Bernhard; van der Putten, Herman; Cryan, John F
Author(s) at UniBasel Bettler, Bernhard
Year 2005
Title Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits
Journal NeuroReport
Volume 16
Number 3
Pages / Article-Number 307-10
Abstract

Metabotropic GABAB receptors predominantly function as heterodimers of GABAB(1) and GABAB(2) subunits, but GABAB(1) can also form functional receptors in the absence of GABAB(2). Mice lacking the GABAB(1) subunit have altered behavioural responses in tests for anxiety and depression. In these studies, we investigated anxiety and depression in GABAB(2)-deficient mice. We compared the effects directly with that of genetic deletion of the GABAB(1) receptor subunit. Both GABAB(1) and GABAB(2)-deficient mice were found to be more anxious than wild type in the light-dark box paradigm. In contrast, these mice exhibited an antidepressant-like behaviour in the forced swim test. Taken together, these data suggest that heterodimeric GABAB(1,2) receptors are required for the normal regulation of emotional behaviour.

Publisher Lippincott Williams & Wilkins
ISSN/ISBN 0959-4965
edoc-URL http://edoc.unibas.ch/dok/A5262239
Full Text on edoc No
Digital Object Identifier DOI 10.1097/00001756-200502280-00021
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/15706241
Document type (ISI) Journal Article
 
   

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