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Long-term exposure to traffic-related PM(10) and decreased heart rate variability : is the association restricted to subjects taking ACE inhibitors?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1634884
Author(s) Adam, M.; Felber, Dietrich; Schaffner, E.; Carballo, D.; Barthélémy, J. C.; Gaspoz, J. M.; Tsai, M. Y.; Rapp, R.; Phuleria, H. C.; Schindler, C.; Schwartz, J.; Künzli, N.; Probst-Hensch, N. M.
Author(s) at UniBasel Probst Hensch, Nicole
Adam, Martin
Felber Dietrich, Denise
Schaffner, Emmanuel
Tsai, Ming-Yi
Rapp, Regula
Phuleria, Harish Chandra
Schindler, Christian
Künzli, Nino
Year 2012
Title Long-term exposure to traffic-related PM(10) and decreased heart rate variability : is the association restricted to subjects taking ACE inhibitors?
Journal Environment international
Volume 48
Pages / Article-Number 9-16
Keywords HRV, Traffic-related PM10, Cardiovascular medication, ACE inhibitors, SAPALDIA
Abstract BACKGROUND: Alterations in heart rate variability (HRV) are a potential link between exposure to traffic-related air pollution and cardiovascular mortality. OBJECTIVES: We investigated whether long-term exposure to traffic-related PM(10) (TPM(10)) is associated with HRV in older subjects and/or in participants taking specific cardiovascular treatment or with self-reported heart disease. METHODS: We included 1607 subjects from the general population aged 50 to 72years. These participants from the SAPALDIA cohort underwent ambulatory 24-hr electrocardiogram monitoring. Associations of average annual exposure to TPM(10) over 10years with HRV parameters from time and frequency domains were estimated using multivariable mixed linear models. Effect estimates are expressed as percent changes in geometric means. RESULTS: HRV was only associated with TPM(10) in participants under ACE inhibitor therapy (N=94). A 1mug/m(3) increment, approximately equivalent to an interquartile range, in 10year average TPM(10) was associated with decrements of 14.5% (95% confidence interval (CI), -25.9 to -1.3) in high frequency (HF) power, of 4.5% (-8.2 to -0.5) in the standard deviation of all normal-to-normal RR intervals (SDNN), of 10.6% (-18.5 to -1.9) in total power (TP) and an increase of 9.2% (0.8 to 20.2) in the LF/HF power ratio. CONCLUSIONS: In the absence of an overall effect our results suggest that alterations in HRV, a measure of autonomic control of the cardiac rhythm, may not be a central mechanism by which long-term exposure to TPM(10) increases cardiovascular mortality. Novel evidence on an effect in persons under ACE inhibitor treatment needs to be confirmed in future studies
Publisher Elsevier
ISSN/ISBN 0160-4120
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.envint.2012.06.016
PubMed ID
ISI-Number WOS:000309796800002
Document type (ISI) Journal Article

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