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Anthelminthic properties of mangostin and mangostin diacetate
Journal
Parasitology international
Volume
61
Number
2
Pages / Article-Number
369-71
Keywords
Garcinia mangostana, Mangostin, Mangostin diacetate, Helminths, In vitro, In vivo
Abstract
Few anthelminthic drugs are available for human use despite the significant burden caused by helminth infections. We studied the activities of mangostin, a major bioactive xanthone isolated from the pericarp and fruit of Garcinia mangostana and of the synthetic derivative mangostin diacetate. Mangostin and mangostin diacetate lacked activity against the nematodes Heligmosomoides polygyrus (third-stage larvae (L3)), Ancylostoma ceylanicum L3, and Trichuris muris adults and showed only low activity against A. ceylanicum adults (IC(50)s of 91mug/ml) in vitro. Mangostin showed promising activities (IC(50) of 2.9-15.6mug/ml) against the trematodes Schistosoma mansoni, Echinostoma caproni and Fasciola hepatica in vitro. Single oral doses (400mg/kg and 800mg/kg) of the drugs achieved worm burden reductions ranging from 0 to 38% and 11-54% against S. mansoni and E. caproni in vivo, respectively. Pharmacokinetic studies would be helpful to understand the differences observed between in vitro and in vivo activities and lacking dose-response relationships
