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Artificial Metalloenzymes: Supramolecular Anchoring and Activation
Third-party funded project |
Project title |
Artificial Metalloenzymes: Supramolecular Anchoring and Activation |
Principal Investigator(s) |
Ward, Thomas R.
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Organisation / Research unit |
Departement Chemie / Bioanorganische Chemie (Ward) |
Project start |
01.07.2013 |
Probable end |
30.06.2016 |
Status |
Completed |
Abstract |
Life emerges from inanimate matter thanks to a complex network of tightly cross-regulated enzymatic reaction cascades. To mimick this, we have emplemented the cross-regulation of an artificial imine reductase which is turned on in the presence of a protease, generating a tripeptide that acts as a cross-regulator for the imine reductase.
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Keywords |
Artificial metalloenzymes, supramolecular catalysis in water, cross-regulation |
Financed by |
Swiss Government (Research Cooperations)
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28/03/2024
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