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Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156903
Author(s) Chih, Ben; Gollan, Leora; Scheiffele, Peter
Author(s) at UniBasel Scheiffele, Peter
Year 2006
Title Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex
Journal Neuron
Volume 51
Number 2
Pages / Article-Number 171-8
Keywords Alternative Splicing/*physiology; Animals; COS Cells; Cells; Cultured; Cercopithecus aethiops; Glycoproteins/genetics/*metabolism; Hippocampus/physiology; Membrane Proteins/genetics/*metabolism; Nerve Tissue Proteins/genetics/*metabolism; Neurons/physiology; Neuropeptides/genetics/*metabolism; Rats; Synapses/*genetics/*metabolism
Abstract Formation of synapses requires specific cellular interactions that organize pre- and postsynaptic compartments. The neuroligin-neurexin complex mediates heterophilic adhesion and can trigger assembly of glutamatergic and GABAergic synapses in cultured hippocampal neurons. Both neuroligins and neurexins are encoded by multiple genes. Alternative splicing generates large numbers of isoforms, which may engage in selective axo-dendritic interactions. We explored whether alternative splicing of the postsynaptic neuroligins modifies their activity toward glutamatergic and GABAergic axons. We find that small extracellular splice insertions restrict the function of neuroligin-1 and -2 to glutamatergic and GABAergic contacts and alter interaction with presynaptic neurexins. The neuroligin isoforms associated with GABAergic contacts bind to neurexin-1alpha and a subset of neurexin-1betas. In turn, these neurexin isoforms induce GABAergic but not glutamatergic postsynaptic differentiation. Our findings suggest that alternative splicing plays a central role in regulating selective extracellular interactions through the neuroligin-neurexin complex at glutamatergic and GABAergic synapses.
Publisher Cell Press
ISSN/ISBN 0896-6273
edoc-URL http://edoc.unibas.ch/dok/A5259850
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.neuron.2006.06.005
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/16846852
ISI-Number WOS:000239535100005
Document type (ISI) Journal Article
 
   

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