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T cell receptor-transgenic mouse models for studying cellular immune responses to Salmonella in vivo
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 156866
Author(s) Bumann, D.
Author(s) at UniBasel Bumann, Dirk
Year 2003
Title T cell receptor-transgenic mouse models for studying cellular immune responses to Salmonella in vivo
Journal FEMS Immunology and Medical Microbiology
Volume 37
Number 2-3
Pages / Article-Number 105-9
Keywords salmonellosis, attenuated live vaccine, T cell induction
Abstract Cellular immune responses are crucial both for protective immunity against salmonellosis, and for the immunogenicity of oral vaccines based on avirulent live Salmonella as antigen carriers. The crucial early steps of T cell induction are difficult to investigate in conventional animals, but recently developed T cell receptor (TCR)-transgenic models allow visualization of antigen-specific T cells in vivo while they become induced. In this review, the results obtained with four different TCR-transgenic Salmonella infection models are described, and advantages and potential limits of each of the different models are compared.
Publisher Elsevier
ISSN/ISBN 0928-8244 ; 1574-695X
edoc-URL http://edoc.unibas.ch/dok/A5259815
Full Text on edoc Available
Digital Object Identifier DOI 10.1016/S0928-8244(03)00064-6
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/12832113
ISI-Number WOS:000184048300004
Document type (ISI) Journal Article, Review
 
   

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